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The precise regulation of O-GalNAc glycosylation

​How do the glycoproteins and glycans synthesized? What’s the biological function of glycoproteins?Based on techniques in biochemistry, molecular biology, cellular biology, experimental animals and computational biology, we constructed glycosyltransferase knockout cells and mice models, discovered novel glycosyltransferase inhibitors, developed glycoproteomic detection and analysis strategies...

Systematic approach for glycomics studies & glycan biomarkers discovery

​Developed an on-chip ppGalNAc-Ts assay that could rapidly and systematically identify the protein substrates of each ppGalNAc-T (Proteomics, 2017), then identified the glycosylated sites and studied the functions of O-GalNAc glycosylation on nucleocytoplasmic protein p53(BBA Gen Subj, 2020).​Synthesized a new kind of Disulfide- and terminal alkyne-functionalized magnetic silica particles for...

Synthetic glycobiology

​Creation of a simple Escherichia coli (E. coli) expression system capable of producing active human ppGalNAc-Ts with potential value for basic research and production of therapeutic O-glycoproteins in vitro(BBRC, 2020

Add.: Room B200, system biomedical research institute, No. 800, Dongchuan Road, Shanghai   Tel.: 86-21-34206966

Research group of Shanghai ICP 11031250 -1 2013 Shanghai Jiao Tong University pollution control

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